期刊
JOURNAL OF ANTIBIOTICS
卷 57, 期 2, 页码 110-116出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.7164/antibiotics.57.110
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Three new beauvericins, designated beauvericins D, E and F, were isolated along with known beauvericin and beauvericin A, from the culture of Beauveria sp. FKI-1366 by solvent extraction, ODS column chromatography and HPLC. These compounds potentiate miconazole activity against not only wild Candida albicans but also fluconazole resistant C. albicans. Beauvericins D and E decreased the IC50 value of miconazole against fluconazole resistant C. albicans from 1.3 mum to 0.25 and 0.31 mum, respectively.
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