期刊
CHEST
卷 125, 期 2, 页码 52S-61S出版社
ELSEVIER SCIENCE BV
DOI: 10.1378/chest.125.2_suppl.52S
关键词
anti-inflammatory activity; asthma; clarithromycin; COPD; erythromycin; macrolides; roxithromycin; sinusitis
In addition to their well-known antimicrobial activity, macrolides possess inummomodulatory properties that may confer beneficial effects to patients with respiratory diseases associated with chronic inflammation. These properties include attenuation of inflammatory responses in the lung, mucoregulatory properties, and effects on bronchial responsiveness. Macrolides increase mucociliary clearance, improve sinusitis symptoms, and decrease nasal secretions and polyp size in patients with sinusitis. They also have been shown to modify the inflammatory response associated with chronic sinusitis. In patients with asthma, macrolides have been reported to reduce airway hyperresponsiveness and improve pulmonary function, and have historically been selected for their steroid-sparing effect. Preliminary data from studies of patients with COPD have shown improvements in symptom scores and FEV, after macrolide treatment. As biological response modifiers, macrolides have the potential to improve the outcomes of patients with inflammatory airway diseases. Large scale, placebo-controlled clinical trials designed to assess long-term efficacy and safety in these diseases are warranted.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据