期刊
BIOLOGICAL PSYCHIATRY
卷 55, 期 3, 页码 263-272出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2003.08.004
关键词
posttraumatic stress disorder; functional connectivity; amygdala; prefrontal; cingulate
Background: Persistent, intrusive re-experiencing in posttraumatic stress disorder (PTSD) is commonly construed as a failure of cingulate inhibition (i.e., extinction) over a hyperresponsive amygdala, based primarily on animal research of fear conditioning and the finding of cingulate hypoperfusion in PTSD. Methods: We examined functional connectivity inpatients with PTSD and healthy trauma survivors during repeated symptom provocation using H2O15 positron emission tomography. Results. Memory retrieval networks (right prefrontal cortex, hippocampus, and visual cortex) were common to both groups. Networks supporting autonomic and emotional control and preparatory motor action (amygdala, anterior cingulate, subcallosal gyrus, and premotor cortex) differed between the two groups and became progressively disparate with successive presentations of the traumatic script. Patterns of effective connectivity demonstrated the predominance of direct influences of the amygdala on visual cortex, subcallosal gyrus, and anterior cingulate in PTSD but not in control subjects. There was little evidence for failure of inhibition of cingulate or subcallosal cortex over the amygdala. Conclusions. These patterns might represent excessive influences of the amygdala over regions involved in autonomic, and higher-order visual memory processing in PTSD. The present data suggest that inferenccs of direct correspondence between animal studies and pathophysiology PTSD should be made with caution.
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