期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 48, 期 2, 页码 673-676出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.48.2.673-676.2004
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Three ovine-derived cathelicidins, SMAP29, OaBac5mini, and OaBac7.5mini, were compared with respect to their antibacterial activities and interactions with membranes. SMAP29 was confirmed to be alpha-helical, broad spectrum, and able to disrupt both the outer and the cytoplasmic membranes at relatively low concentrations. In contrast, the two proline- and arginine-rich OaBac peptides had more-modest antibacterial activities, reduced levels of lipopolysaccharide binding, and a lesser ability to depolarize the cytoplasmic membrane, consistent with a cytoplasmic target.
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