期刊
NATURE IMMUNOLOGY
卷 5, 期 2, 页码 159-168出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1026
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- NIAID NIH HHS [AI 42767, AI 50073, T32 AI 07260, T32 AI 07485, T32 AI 07511, AI 46653] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007337] Funding Source: Medline
Listeria monocytogenes infection generates major histocompatibility complex (MHC) class Ia-restricted and MHC class Ib-(H2- M3)-restricted effector and memory CD8(+) T cells. However, only MHC class Ia-restricted memory cells expand after rechallenge, and it is unknown if MHC class Ib-restricted memory CD8(+) T cells generated by vaccination are protective. We show here that H2- M3-restricted memory CD8(+) T cells were capable of secondary expansion but, in contrast to primary H2-M3-restricted effector cells, failed to provide protective immunity. In LM-immune mice, MHC class Ia- restricted memory CD8(+) T cells prevented the expansion of H2-M3-restricted memory T cell populations by limiting dendritic cell antigen presentation. Thus, protective immunity by H2-M3-resricted T cells is limited to primary infection, indicating that memory MHC class Ia- restricted T cells prevent nonessential immune responses during secondary infection.
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