期刊
JOURNAL OF MEDICAL VIROLOGY
卷 72, 期 2, 页码 187-193出版社
WILEY-BLACKWELL
DOI: 10.1002/jmv.10578
关键词
hepatitis; anti retroviral therapy; immunoglobulin
类别
资金
- MRC [G0200000] Funding Source: UKRI
- Medical Research Council [G0200000] Funding Source: researchfish
- Medical Research Council [G0200000] Funding Source: Medline
The effect of highly active antiretroviral therapy (HAART) on HCV replication is controversial, with some studies reporting no effect and others increases, reductions and even clearances of HCV RNA after treatment. In this study, the effect of HAART was investigated on the titre of anti-HCV specific antibodies and on the relationship between these antibodies and HCV RNA level in a cohort of 24 patients with inherited bleeding disorders. A significant inverse correlation between antibodies to both total HCV proteins and HCV RNA (R = -0.42, P = 0.05) and between antibodies to HCV envelope glycoproteins and HCV RNA (R = -0.54, P = 0.01) was observed pre-HAART. The relationship disappeared or was obscured after therapy (R = 0.24, P = 0.30 and R = 0.16, P = 0.50, respectively). Thus, we show that HAART affects the HCV specific humoral immune responses without affecting the HCV RNA level. (C) 2004 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据