期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 29, 期 2, 页码 95-102出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2003.12.004
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资金
- NIA NIH HHS [R01 AG021045-03, R01 AG021045] Funding Source: Medline
- NIMH NIH HHS [R01 MH038752-20] Funding Source: Medline
- NINDS NIH HHS [R01 NS037768-03, R01 NS037768] Funding Source: Medline
Glycogen synthase kinase-3 (GSK3) is now recognized as a key component of a surprisingly large number of cellular processes and diseases. Several mechanisms play a part in controlling the actions of GSK3, including phosphorylation, protein complex formation, and subcellular distribution. These are used to control and direct the far-reaching influences of GSK3 on cellular structure, growth, motility and apoptosis. Dysregulation of GSK3 is linked to several prevalent pathological conditions, such as diabetes and/or insulin resistance, and Alzheimer's disease. Therefore, much effort is currently directed towards understanding the functions and control of GSK3, and identifying methods capable of diminishing the deleterious impact of GSK3 in pathological conditions.
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