期刊
ARCHIVES OF DISEASE IN CHILDHOOD
卷 98, 期 8, 页码 592-595出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/archdischild-2012-303441
关键词
Sleep; Respiratory
类别
Objectives To describe breathing patterns in infants with Prader-Willi Syndrome (PWS), as well as the effects of supplemental oxygen (O-2) on breathing patterns. Children with PWS commonly have sleep-disordered breathing, including hypersomnolence and obstructive sleep apnoea, as well as central sleep breathing abnormalities that are present from infancy. Design Retrospective cohort study. Patients Infants with a diagnosis of PWS. Setting Tertiary children's hospital. Interventions Infants with PWS underwent full polysomnography, and in those with frequent desaturations associated with central events, supplemental O-2 during sleep was started and followed with regular split-night studies (periods in both air and O-2). Results Thirty split-night studies on 10 infants (8 female) aged 0.06-1.79 (median 0.68, IQR 0.45, 1.07) years were undertaken. At baseline (ie, air), children with PWS had a median (IQR) central apnoea index (CAI) of 4.7 (1.9, 10.6) per hour, with accompanying falls in oxygen saturation (SpO(2)). O-2 therapy led to statistically significant reductions in CAI to 2.5/hour (p=0.002), as well as a reduced central event index (CEI) and improved SpO(2). No change in the number of obstructive events was noted. Central events were more prevalent in rapid-eye movement/active sleep. Conclusions It is concluded that infants with PWS may have central sleep-disordered breathing, which, in some children, may cause frequent desaturations. Improvements in CAI and CEI as well as oxygenation were noted with O-2 therapy. Longitudinal work with this patient group would help to establish the timing of onset of obstructive symptoms.
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