期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 63, 期 35, 页码 7760-7764出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.5b02766
关键词
advanced glycation end products (AGEs); pomegranate; ellagic acid; punicalagin; diabetes
资金
- Ministry of Agriculture, Forestry and Fisheries Green and Water Environment Technology and Innovation Project, The 6th Industry Generation for Agriculture, Forestry and Fisheries Community Program
Accumulation of advanced glycation end products (AGEs) leads to various diseases such as diabetic complications and arteriosclerosis. In this study, we examined the effect of pomegranate fruit extract (PFE) and its constituent polyphenols on AGE formation in vivo and in vitro. PFE, fed with a high-fat and high-sucrose (HFS) diet to KK-A(y) mice, significantly reduced glycation products such as glycoalbumin (22.0 +/- 2.4%), hemoglobin A1c (5.84 +/- 0.23%), and serum AGEs (8.22 +/- 0.17 mu g/ mL), as compared to a control HFS group (30.6 +/- 2.6%, 7.45 +/- 0.12%, and 9.55 +/- 0.17 mu g/mL, respectively, P < 0.05). In antiglycation assays, PFE, punicalin, punicalagin, ellagic acid, and gallic acid suppressed the formation of AGEs from bovine serum albumin and sugars. In this study, we discuss the mechanism of the antiglycation effects of PFE and its components in vivo and in vitro.
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