期刊
SYNAPSE
卷 51, 期 2, 页码 158-164出版社
WILEY
DOI: 10.1002/syn.10288
关键词
5-HT6; receptor; dopamine; medial prefrontal cortex; microdialysis; norepinephrine; SB-271046; serotonin
The present study investigated the neurochemical effects of the selective 5-HT6 receptor antagonist SB-271046 in the rat medial prefrontal cortex (mPFC). The effect of SB-271046 on extracellular levels of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) in the mPFC was examined using in vivo microdialysis in the freely moving rat. SB-271046 (10 mg/kg, p.o.) produced a significant increase in extracellular levels of both DA and NE without altering 5-HT neurotransmission. These results further support the rationale for the use of 5-HT6 receptor antagonists in the treatment of cognitive dysfunction associated with psychiatric diseases. (C) 2003 Wiley-Liss, Inc.
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