期刊
CHEMICAL SENSES
卷 29, 期 2, 页码 143-152出版社
OXFORD UNIV PRESS
DOI: 10.1093/chemse/bjh019
关键词
discrimination ability; enantiomers; humans; odor structure-activity relationships; olfaction
The ability of 20 human subjects to distinguish between nine enantiomeric odor pairs sharing an isopropenyl group at the chiral center was tested in a forced-choice triangular test procedure. I found (i) that as a group, the subjects were only able to significantly discriminate the optical isomers of limonene, carvone, dihydrocarvone, dihydrocarveol and dihydrocarvyl acetate, whereas they failed to distinguish between the (+)- and (-)-forms of perillaalcohol, perillaaldehyde, isopulegol and limonene oxide; (ii) marked interindividual differences in discrimination performance, ranging from subjects who were able to significantly discriminate between eight of the nine odor pairs to subjects who failed to do so with six of the nine tasks; and (iii) that with none of the nine odor pairs the antipodes were reported to differ significantly in subjective intensity when presented at equal concentrations. Additional tests of the chemesthetic potency and threshold measurements of the optical isomers of dihydrocarvone, dihydrocarveol, and dihydrocarvyl acetate suggest that the discriminability of these three enantiomeric odor pairs is indeed due to differences in odor quality. Analysis of structure-activity relationships suggest that the combined presence of (i) an isopropenyl group at the chiral center; (ii) a methyl group at the para-position; and/or (iii) an oxygen-containing group at the meta-position allows for the discrimination of enantiomeric odor pairs.
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