期刊
ACTA ORTHOPAEDICA SCANDINAVICA
卷 75, 期 1, 页码 93-99出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00016470410001708190
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Background Blood platelets release a cocktail of growth factors when activated, some of which are thought to initiate and stimulate repair. Experiment and findings We studied whether a platelet concentrate injection would improve Achilles tendon repair in an established rat model. The Achilles tendon was transected and a 3 mm segment removed. After 6h, a platelet concentrate was injected percutaneously into the hematoma. This increased tendon callus strength and stiffness by about 30% after 1 week, which persisted for as long as 3 weeks after the injection. At this time, the mechanical testing indicated an improvement in material characteristics-i.e., greater maturation of the tendon callus. This was confirmed by blinded histological scoring. Interpretation Platelet concentrate may prove useful for the treatment of Achilles tendon ruptures.
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