期刊
IUBMB LIFE
卷 56, 期 2, 页码 89-93出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15216540410001668055
关键词
calcium channel; sodium channel; norepinephrine transporter; nicotinic acetylcholine receptor; NMDA receptor; neurotensin receptor
Cone snails have evolved a vast array of peptide toxins for prey capture and defence. These peptides are directed against a wide variety of pharmacological targets, making them an invaluable source of ligands for studying the properties of these targets in normal and diseased states. A number of these peptides have shown efficacy in vivo, including inhibitors of calcium channels, the norepinephrine transporter, nicotinic acetylcholine receptors, NMDA receptors and neurotensin receptors, with several having undergone pre-clinical or clinical development for the treatment of pain.
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