期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 15, 期 1, 页码 63-74出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2003.09.001
关键词
Chx10; Six6; Rx; cyclin D1; p27Kip1
资金
- NEI NIH HHS [R01-EY013760, F32-EY13922, R01 EY013760-03, R01 EY013760] Funding Source: Medline
The proliferative expansion of retinal progenitor cells (RPCs) is a fundamental mechanism of growth during vertebrate retinal development. Over the past couple of years, significant progress has been made in identifying genes expressed in RPCs that are essential for their proliferation, and the molecular mechanisms are beginning to be resolved. In this review, we highlight recent studies that have identified regulatory components of the RPC cell cycle machinery and implicate a set of homeobox genes as key regulators of proliferative expansion in the retina. (C) 2003 Elsevier Ltd. All rights reserved.
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