期刊
TRENDS IN GENETICS
卷 20, 期 2, 页码 87-94出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2003.12.008
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资金
- Medical Research Council [G9810900] Funding Source: Medline
- MRC [G9810900] Funding Source: UKRI
- Medical Research Council [G9810900] Funding Source: researchfish
Microarray-based comparative genomic hybridization (array-CGH) has emerged as a revolutionary platform, enabling the high-resolution detection of DNA copy number aberrations. In this article we outline the use and limitations of genomic clones, cDNA clones and PCR products as targets for genomic microarray construction. Furthermore, the applications and future aspects of these arrays for DNA copy number analysis in research and diagnostics, epigenetic profiling and gene annotation are discussed. These recent developments of genomic microarrays mark only the beginning of a new generation of high-resolution and high-throughput tools for genetic analysis.
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