期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 15, 期 1, 页码 13-19出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2003.10.002
关键词
HB-EGF; ADAMs; ectodomain shedding; PLZF; intracellular signaling
Heparin-binding EGF-like growth factor (HB-EGF), a member of the EGF family, is synthesized as a membrane-anchored precursor (proHB-EGF) that is cleaved to release a soluble HB-EGF by specific metalloproteases. Proteolytic cleavage of proHB-EGF yields amino- and carboxy-terminal fragments (HB-EGF and HB-EGF-C). Recent studies indicate that the processing of proHB-EGF is strictly regulated and involved in a variety of biological processes and that not only HB-EGF but also HB-EGF-C functions as a signaling molecule. ProHB-EGF generates dual intracellular signaling molecules by its proteolytic cleavage. (C) 2003 Elsevier Ltd. All rights reserved.
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