期刊
NUCLEAR MEDICINE AND BIOLOGY
卷 31, 期 2, 页码 297-301出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nucmedbio.2003.07.002
关键词
Y-86 purification; Sr-Spec resin; RE-Spec resin; Aminex A5 resin; semi-automation
The separation of Y-86 from Sr-86 was optimized by a semi-automated purification system involving the passage of the target sample through three sequential columns. The target material was dissolved in 4 N HNO3 and loaded onto a Sr-selective (Sr-Spec) column to retain the Sr-86. The yttrium was eluted with 4 N HNO3 onto the second Y-selective (RE-Spec) column with quantitative retention. The RE-Spec column was eluted with a stepwise decreasing concentration of HNO3 to wash out potential metallic impurities to a waste container. The eluate was then pumped onto an Aminex A5 column with 0.1 N HCl and finally with 3 N HCl to collect the radioyttrium in 0.6-0.8 mL with a >80% recovery. This method enabled us to decontaminate Sr by 250,000 times and label 30 mug of DOTA-Biotin with a >95% yield. (C) 2004 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据