期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 19, 期 1, 页码 33-38出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756360310001650219
关键词
pyrazoloquinoline nucleosides; cytotoxicity; anti-HSV-1; acute toxicity
Synthesis of a novel series of structurally related pyrazoloquinoline nucleosides is described. All the newly synthesized compounds were examined for their in vitro antiviral activity against herpes simplex type-1 as shown by two different bioassays, namely; crystal violet staining or the MTS tetrazolium dye measurement. The acute toxicity (LD50) values of the biologically active compounds were determined.
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