期刊
HUMAN IMMUNOLOGY
卷 65, 期 2, 页码 157-162出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2003.10.005
关键词
HLA class I; HLA-G; free heavy chain; activated lymphocytes; 4H84
类别
We have found that 4H84 monoclonal antibody (mAb) used for detection of beta(2)M free HLA-G molecules also binds to free heavy chains of classical HLA class I antigens generated on the cell surface by mild acid treatment. Here we demonstrate that beta(2)m free classical HLA class I molecules induced on the surface of activated lymphocytes not expressing HLA-G also bind 4H84 mAb. These results demonstrate that 4H84 mAb should be used for detection of HLA-G in cells and tissues with backing by other HLA-G specific mAbs.
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