期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 122, 期 2, 页码 239-245出版社
ELSEVIER SCIENCE INC
DOI: 10.1046/j.0022-202X.2004.22224.x
关键词
dermal papilla; wnt; hair follicle; regeneration
类别
Dermal papilla cells of the hair follicle can be maintained in an active, hair-inducing state in vitro when cocultured with cells secreting Wnt3a. By inducing cultured dermal papilla cells to secrete Wnt themselves, we demonstrate that this activity is a direct effect of Wnt signaling to dermal papilla cells. We further demonstrate that the effects of Wnt3a are exerted through activation of the beta-catenin signal transduction pathway and do not require alternative Wnt transduction cascades. Once dermal papilla cells have lost hair-inducing properties in vitro, neither treatment with Wnt nor expression of a truncated and activating form of beta-catenin is sufficient to restore these properties to the cultured cells.
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