期刊
TRENDS IN GENETICS
卷 20, 期 2, 页码 59-62出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2003.12.006
关键词
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资金
- NINDS NIH HHS [NS32130] Funding Source: Medline
Traditionally, knockout experiments are performed in ES cells derived from the 129 mouse strain, followed by backcrossing with the more robust C57BL/6 strain. C57BL/6-derived ES cells have only occasionally been used in this process. We compared C57BL/6- with 129-derived ES cells directly and reviewed the literature. We found that, although some steps are less efficient, the advantages of C57BL/6 mice more than compensate for these drawbacks.
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