The role of serum immunoglobulin E in the pathogenesis of Plasmodium falciparum malaria in Ivorian children

The aim of the study was to determine the role of immunoglobulin E (IgE) in the pathogenesis of Plasmodium falciparum malaria in Ivorian children. The study comprised of 90 Ivorian children of both sexes, aged 6-72 months: 30 children suffering from severe malaria, 30 suffering from mild malaria and 30 in good heath (serving as the control population). The children underwent a total serum IgE test for the determination of haemoglobin and platelet level and parasite density. We noted a significant rise in IgE level in the children affected with malaria. The level was higher when the malaria was more severe, increasing from 84.61 kUI/l in the control children to 339.9 kUI/l in the children with mild malaria and 659.9 kUI/l in children with severe malaria. Among the comatose patients with severe malaria, the increase in IgE level was related to the level of deterioration of the consciousness. Moreover, we noted a negative correlation between IgE level and the level of haemoglobin and between the IgE level and platelet level. These results are in accordance with the results found in literature and confirm the use of IgE level as an indicator of P. falciparum malaria.