期刊
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
卷 24, 期 1-2, 页码 85-105出版社
TAYLOR & FRANCIS LTD
DOI: 10.1081/RRS-120034252
关键词
F11 receptor; F11R; junctional adhesion molecule; JAM; JAM-1; JAM-A; PI-3 kinase; calcium ions; platelet aggregation; cell adhesion molecule (CAM); F11 receptor dimerization; integrin GPIIIa
资金
- NHLBI NIH HHS [HL0241203] Funding Source: Medline
The F11 receptor (F11R) (a.k.a. Junctional Adhesion Molecule, JAM) was first identified in human platelets as a 32/35 kDa protein duplex that serves as receptor for a functional monoclonal antibody that activates platelets. We have sequenced and cloned the F11R and determined that it is a member of the immunoglobulin (Ig) superfamily of cell adhesion molecules. The signaling pathways involved in F11R-induced platelet activation were examined in this investigation. The binding of M.Ab.F11 to the platelet F11R resulted in granule secretion and aggregation.
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