期刊
TRENDS IN MOLECULAR MEDICINE
卷 10, 期 2, 页码 78-84出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2003.12.007
关键词
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There is emerging evidence to suggest that the unregulated Ca2+-mediated proteolysis of essential lens proteins by calpains might be a major contributor to some forms of cataract in both animals and humans. Moreover, recently solved calpain structures have revealed molecular-level details of the activation mechanism used by these proteases, enabling the structure-based design of potent calpain inhibitors with the potential to act as anti-cataract agents. These agents offer the first real hope of an urgently needed alternative to the surgical treatment of at least some forms of cataract and relief from a life-depreciating condition on a global scale.
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