期刊
MULTIPLE SCLEROSIS JOURNAL
卷 10, 期 1, 页码 2-4出版社
SAGE PUBLICATIONS LTD
DOI: 10.1191/1352458504ms988oa
关键词
cerebrospinal fluid; Devic's syndrome; multiple sclerosis; neuromyelitis optica; oligodonal bands
We studied repeated cerebrospinal fluids of patients with Devic's neuromyelitis optica (NMO) and multiple sclerosis (MS). Variations of oligoclonal bands (OBs) had opposite trends in the two groups. In MS, OBs were detected in 399 of 411 patients (97%.) and never disappeared. In NMO, OBs were detected in three of 11 patients (27%) and always disappeared. The hypothesis that NMO and MS follow distinct pathogenetic pathways is supported by our findings, which can be useful for the differentiation of NMO from MS.
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