期刊
NATURE MEDICINE
卷 10, 期 2, 页码 143-145出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm986
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资金
- NCI NIH HHS [CA 90301] Funding Source: Medline
- NIAID NIH HHS [R01 AO34969, R01 AI034969] Funding Source: Medline
To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23% of the children had actually died from other causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75% of those had additional intra- and perivascular pathology. Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical trials and assessing malaria-specific disease associations.
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