期刊
JOURNAL OF NEUROTRAUMA
卷 21, 期 2, 页码 149-161出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/089771504322778613
关键词
2-deoxy-2-[F-18]fluoro-D-glucose; glucose; lumped constant; metabolism; positron emission tomography; traumatic brain injury
资金
- NIDCR NIH HHS [DE-FC03-02ER63420, DE FC0387-ER60615] Funding Source: Medline
- PHS HHS [30308] Funding Source: Medline
The aim of this study was to determine whether the apparent loss of overall gray-white matter contrast (GNMM) seen on FDG-PET imaging reflects the differential changes of glucose metabolic rate (CMRglc) in cortical gray mater (GM) and subcortical white mater (WM) following TBI. The clinical significance of the CMRglc GM-to-WM ratio was also evaluated. Nineteen normal volunteers and 14 TBI patients were studied. Each subject had a quantitative FDG-PET, a quantitative (H2O)-O-15- PET and a MR scan acutely following TBI. Stabilities of the global and regional FDG lumped constants (LC) were studied. Parametric images (pixel unit: mg/min/100g) of FDG uptake rate (CURFDG) and CMRglc were generated. The changes of CMRglc in whole brain, GM and WM were studied separately by using a MRI-segmentation-based technique. The GM-to-WM ratios of both CURFDG and CMRglc images were significantly (p < 0.001) decreased (>31%) in TBI patients. The global LC value reduced significantly (p < 0.01) in TBI patients. The CMRglc decreased significantly (p < 0.001) in GM but not in WM (p > 0.1). Kinetic analysis revealed significant (P < 0.001) decrease of GM hexokinase activity in TBI patients. The GM-to-WM ratios of CMRgl, correlated (r = 0.64) with the initial Glasgow Coma Score (GCS) of TBI patients. The patients with higher CMRglc GM-to-WM ratios (>1.54) showed good recovery 12 months after TBI. There was a selective CMRglc reduction in cortical GM following TBI. The pathophysiological basis for the reduction in GM-to-WM CMRglc ratio seen on FDG-PET imaging following TBI remains to be determined.
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