期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 8, 期 1, 页码 66-75出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2003.12.001
关键词
-
资金
- NCI NIH HHS [R33 CA93302] Funding Source: Medline
- NHLBI NIH HHS [N01-HV-28179] Funding Source: Medline
- NIDA NIH HHS [1P30DA01562501] Funding Source: Medline
Quantitative proteome profiling using mass spectrometry and stable isotope dilution is being widely applied for the functional analysis of biological systems and for the detection of clinical, diagnostic or prognostic marker proteins. Because of the enormous complexity of proteomes, their comprehensive analysis is unlikely to be routinely achieved in the near future. However, in recent years, significant progress has been achieved focusing quantitative proteomic analyses on specific protein classes or subproteomes that are rich in biologically or clinically important information. Such projects typically combine the use of chemical probes that are specific for a targeted group of proteins and may contain stable isotope signatures for accurate quantification with automated tandem mass spectrometry and bioinformatics tools for data analysis. In this review, we summarize technical and conceptual advances in quantitative subproteome profiling based on tandem mass spectrometry and chemical probes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据