期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 147, 期 1-2, 页码 127-130出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2003.10.027
关键词
acanthameba; cannabinoids; cytokines; delta-9-tetrahydrocannabinol; granulomatous Amebic encephalitis (GAE); opportunistic amebae
资金
- NIDA NIH HHS [DA 05832, DA 05274] Funding Source: Medline
Recent reports indicate a higher frequency of brain infections with opportunistic amebae of the genus Acanthamoeba among immune compromised individuals, including AIDS patients. We have demonstrated, using a murine model of Granulomatous Amebic Encephalitis (GAE), that the major psychoactive and immune suppressive component in marijuana delta-9-tetrahydrocannabinol (THC) exacerbates infection by these amebae. Mice administered THC and infected with Acanthamoeba exhibited dose-related higher mortalities than infected vehicle controls. The greater severity of disease for THC-treated mice was accompanied by decreased accumulation of macrophage-like cells at focal sites of infection in the brain. Furthermore, THC administration resulted in decreased levels of mRNA for the pro-inflammatory cytokines interleukin-1alpha, interleukin-1beta, and tumor necrosis factor a for neonatal rat microglia co-cultured with Acanthamoeba. These results indicate a potential for marijuana to alter the capacity of brain macrophage-like cells to mount a full complement of immune responsiveness to brain infection by opportunistic amebae. (C) 2003 Elsevier B.V. All rights reserved.
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