期刊
JOURNAL OF CELL BIOLOGY
卷 164, 期 3, 页码 417-426出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200307048
关键词
chaoptin; photoreceptor; Drosophila; amphiphysin; moesin
类别
资金
- NEI NIH HHS [F32 EY006979, R01 EY006979, EY06979] Funding Source: Medline
- NIDCD NIH HHS [F32 DC000432, DC00432-02] Funding Source: Medline
Microvilli are actin-based fingerlike membrane projections that form the basis of the brush border of enterocytes and the Drosophila melanogaster photoreceptor rhabdomere. Although many microvillar cytoskeletal components have been identified, the molecular basis of microvillus formation is largely undefined. Here, we report that the Wiskott-Aldrich syndrome protein (WASp) is necessary for rhabdomere microvillus morphogenesis. We show that WASp accumulates on the photoreceptor apical surface before microvillus formation, and at the time of microvillus initiation WASp colocalizes with amphiphysin and moesin. The loss of WASp delays the enrichment of F-actin on the apical photoreceptor surface, delays the appearance of the primordial microvillar projections, and subsequently leads to malformed rhabdomeres.
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