期刊
SCIENCE
卷 303, 期 5659, 页码 836-839出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1091325
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资金
- NCI NIH HHS [CA87038] Funding Source: Medline
- NIGMS NIH HHS [GM 68695, GM 62939, GM 44585] Funding Source: Medline
Microtubule (MT) stabilization is regulated by the small guanosine triphosphate (GTP)-binding protein Rho and its effector, mammalian homolog of Diaphanous (mDia), in migrating cells, but factors responsible for localized stabilization at the leading edge are unknown. We report that integrin-mediated activation of focal adhesion kinase (FAK) at the leading edge is required for MT stabilization by the Rho-mDia signaling pathway in mouse fibroblasts. MT stabilization also involved FAK-regulated localization of a lipid raft marker, ganglioside G(M1), to the leading edge. The integrin-FAK signaling pathway may facilitate Rho-mDia signaling through G(M1), or through a specialized membrane domain containing G(M1), to stabilize MTs in the leading edge of migrating cells.
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