期刊
SCIENCE
卷 303, 期 5659, 页码 839-842出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1092571
关键词
-
资金
- NHLBI NIH HHS [HL 20948] Funding Source: Medline
- NIGMS NIH HHS [R01 GM47214, GM52016] Funding Source: Medline
Translocation of the small GTP-binding protein Rac1 to the cell plasma membrane is essential for activating downstream effectors and requires integrin-mediated adhesion of cells to extracellular matrix. We report that active Rac1 binds preferentially to low-density, cholesterol-rich membranes, and specificity is determined at least in part by membrane lipids. Cell detachment triggered internalization of plasma membrane cholesterol and lipid raft markers. Preventing internalization maintained Rac1 membrane targeting and effector activation in nonadherent cells. Regulation of lipid rafts by integrin signals may regulate the location of membrane domains such as lipid rafts and thereby control domain-specific signaling events in anchorage-dependent cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据