期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 10, 期 3, 页码 588-593出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200305288
关键词
artificial viruses; gene delivery; macrocyclic glycoclusters; nanostructures; self-assembly
Macrocyclic glycocluster amphiphiles are intended to be a covalent-bundle mimic of clustering glycolipid motifs on the cell membrane. They are irreversibly micellized to give glycocluster nanoparticles (GNPs); their masked hydrophobicity endows them with remarkable saccharide specificities in the interactions with biological saccharide receptors. The GNPs also exhibit unprecedented hydrogen-bond capacities; they are agglutinated with Na2HPO4 and assembled on plasmid DNA in a number-, size-, and shape-controlled manner to give artificial glycoviral particles capable of transfection. Thus, the intrinsic function of viruses, that is, cell invasion followed by gene expression, is also intrinsic to size-regulated (similar to50 nm) glycoviruses. The growth of glycocluster amphiphiles through nanoparticles to glycoviruses reveals a hierarchical adhesion control of the saccharide clusters.
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