期刊
TETRAHEDRON
卷 60, 期 7, 页码 1665-1669出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2003.11.091
关键词
natural product; antitumor; tanshinone diterpene; dihydroxytashinone; Diels-Alder cycloaddition; ultrasound; total synthesis
The first synthesis of 3(S),17-dihydroxytanshinone was achieved by ultrasound promoted Diels-Alder reaction of the protected 3-hydroxymethyl-4,5-benzofurandione with a vinylcyclohexene derivative. Bioassay showed that the synthetic 3(S), 17-dihydroxytanshinone was active in vitro against HL-60 tumor cell line by MTT method. (C) 2003 Elsevier Ltd. All rights reserved.
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