期刊
TETRAHEDRON LETTERS
卷 45, 期 7, 页码 1489-1493出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2003.12.026
关键词
alkyl chalcone; dihydropyrazole; cyclization; aryl cuprate addition; propargylic ketone
We report a simple and efficient two-step synthesis of variously substituted beta-alkyl chalcones (7) from the corresponding Weinreb amide and a terminal alkyne, and that these chalcones are useful intermediates for the synthesis of medicinally interesting 3,5-diaryl-5-alkyl-4,5-dihydropyrazoles (6). The current methodology allows for the incorporation of many substitution patterns not available from the few previously reported approaches to compounds in this class. (C) 2003 Elsevier Ltd. All rights reserved.
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