期刊
BRITISH JOURNAL OF CANCER
卷 90, 期 3, 页码 686-692出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6601603
关键词
ovarian cancer; gene expression microarrays; biomakers; MGB2
类别
Ovarian cancer has the highest mortality rate of gynaecological cancers. This is partly due to the lack of effective screening markers. Here, we used oligonucleotide microarrays complementary to similar to12 000 genes to establish a gene-expression microarray (GEM) profile for normal ovarian tissue, as compared to stage III ovarian serous adenocarcinoma and omental metastases from the same individuals. We found that the GEM profiles of the primary and secondary tumours from the same individuals were essentially alike, reflecting the fact that these tumours had already metastasised and acquired the metastatic phenotype. We have identified a novel biomarker, mammaglobin-2 (MGB2), which is highly expressed specific to ovarian cancer. MGB2, in combination with other putative markers identified here, could have the potential for screening.
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