期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 56, 期 2, 页码 145-172出版社
ELSEVIER
DOI: 10.1016/j.addr.2003.09.001
关键词
closed-loop insulin delivery; MEMS; microfluidics; phenylboronic acid; hydrogels; glucose-sensitive
Recent development in microfabrication (micromachining, microelectromechanical systems, MEMS) permits the integration of hard and soft structures, and enables the design of controllable microfluidic systems, which may be applied to drug delivery. In this paper, we present a tutorial review of both classical hard and more recent soft micromachining techniques. We then provide examples where these techniques are combined to produce hydrogel-based microfluidic control systems. The most complex of these systems utilizes a very small hydrogel based on phenylboronic acid to control the flow of an insulin solution in response to changes in glucose concentration. (C) 2003 Elsevier B.V. All rights reserved.
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