期刊
CANCER LETTERS
卷 204, 期 1, 页码 87-95出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2003.09.018
关键词
angiogenesis; endostatin; primary breast cancer; vascular endothelial growth factor
类别
Serum vascular endothelial growth factor (VEGF) and endostatin levels were detected in 59 patients with breast cancer before surgery and at 3 weeks after surgery. Pre-operatively, their levels were significantly elevated and correlated with each other. Post-operatively, VEGF level decreased significantly and endostatin remained at a high level. Patients with both normalized VEGF and elevated endostatin following surgery had a lower risk of relapse than patients whose VEGF failed to normalize. Univariate and multivariate analyses showed a correlation between elevated VEGF level and short free-relapse survival. These findings suggest a new angiogenesis balance is formed in the patients after surgery and such a resultant balance may be beneficial for the prognosis of breast cancer, which deserves more extensive study. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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