期刊
FEBS LETTERS
卷 559, 期 1-3, 页码 1-5出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(04)00050-X
关键词
lipid raft; cholesterol; sphingolipid; detergent
资金
- Biotechnology and Biological Sciences Research Council [C16435] Funding Source: Medline
- Wellcome Trust [070835] Funding Source: Medline
The relative insolubility of lipid rafts in cold nonionic detergents is the most widely used method to purify these fascinating membrane domains from intact cells or membranes. Most of what we know about lipid raft function has been derived from experiments utilising detergent insolubility as the basis for raft purification. Recently, a wider range of detergents have been used to purify 'rafts', and rafts have been subclassified based on their differential solubility in different detergents. This minireview critically examines the use of detergents as tools for raft isolation and for the subclassification of rafts. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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