期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 33, 期 3-4, 页码 199-204出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2003.09.007
关键词
liposomes; cisplatin; drug encapsulation; Pt EXAFS; supersaturated solution
The anticancer agent cisplatin encapsulated in sterically stabilized liposomes is studied with extended X-ray absorption fine structure (EXAFS) method. Analysis of local atomic structure around Pt atoms clearly indicates that the liposome-encapsulated drug is chemically stable and does not hydrolyze. Cisplatin forms a supersaturated solution in the liposome interior at a concentration about eight-fold above its aqueous solubility. (C) 2003 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据