期刊
BIOLOGICAL PSYCHIATRY
卷 55, 期 4, 页码 367-375出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2003.10.007
关键词
glucocorticoid receptor; mineralocorticoid receptor; maternal separation; HPA axis; dexamethasone
资金
- NIMH NIH HHS [MH 12163, MH 58922, MH 50113] Funding Source: Medline
Background: Maternally separated rats exhibit exaggerated hypothalamic-pituitary-adrenal responses to an acute stressor but normal diurnal trough functioning. We hypothesized that maternally separated rats experience adequate proactive glucocorticoid negative feedback but deficient reactive negative feedback, contributing to prolonged hypothalamic-pituitary-adrenal stress responses. Methods: We measured plasma adrenocorticotropic hormone and corticosterone concentrations following an acute stressor or 6 to 8 hours after dexamethasone administration in adult rats previously exposed to daily handling-maternal separation for 15 minutes (HMS15) or 180 minutes (HMS180) during postnatal days 2 to 14. We also examined regional mineralocorticoid receptor and glucocorticoid receptor messenger RNA density in these two groups. Results. HMS180 rats appeared to escape dexamethasone suppression of plasma adrenocorticotropic hormone and corticosterone faster than their HMS15 counterparts (p < .01). In situ hybridization analysis revealed increased hippocampal mineralocorticoid receptor messenger RNA density (p < .05) with decreased cortical (p < .05) and hippocampal (p < .05) glucocorticoid receptor messenger RNA density in HMS180 versus HMS15 animals. Conclusions: These results are consistent with the hypothesis that in rats exposed to moderate neonatal handling-maternal separation, enhanced proactive feedback maintains the hypothalamic-pituitary-adrenal axis during the diurnal trough, while decreased reactive feedback contributes to prolonged responsiveness of the hypothalamic-pituitary-adrenal axis following an acute stressor.
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