期刊
STATISTICS IN MEDICINE
卷 23, 期 3, 页码 369-388出版社
WILEY
DOI: 10.1002/sim.1599
关键词
centre effects; frailty models; multicentre trials; survival analysis; treatment-by-centre interaction
类别
资金
- NHLBI NIH HHS [HL 65411] Funding Source: Medline
In randomized clinical trials, subjects are recruited at multiple study centres. Factors that vary across centres may exert a powerful independent influence on study outcomes. A common problem is how to incorporate these centre effects into the analysis of censored time-to-event data. We survey various methods and find substantial advantages in the gamma frailty model. This approach compares favourably with competing methods and appears minimally affected by violation of the assumption of a gamma-distributed frailty. Recent computational advances make use of the gamma frailty model a practical and appealing tool for addressing centre effects in the analysis of multicentre trials. Copyright (C) 2004 John Wiley Sons, Ltd.
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