期刊
BRAIN RESEARCH BULLETIN
卷 62, 期 6, 页码 455-459出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2003.07.005
关键词
nitric oxide; retinal ganglion cell; neurodegeneration; intraocular pressure; rat; fluoro-gold; optic nerve
资金
- NEI NIH HHS [EY 12017] Funding Source: Medline
Excessive nitric oxide, generated by inducible NOS-2 in astrocytes and microglia in the optic nerve head of patients with glaucoma, may contribute to the optic neuropathy associated with the disease. A rat model of glaucoma, in which there is chronic, moderately elevated IOP and slow loss of retinal ganglion cells, has been established to study pharmacological agents that have the potential to be neuroprotective. In this model, the pharmacological use of an inhibitor of NOS-2, aminoguanidine, significantly prevents the loss of retinal ganglion cells. A well-tolerated pharmacological inhibitor of NOS-2, perhaps orally or locally delivered, is a reasonable candidate for a neuroprotective agent for treating glaucoma. (C) 2003 Elsevier Inc. All rights reserved.
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