期刊
BIOLOGICAL PSYCHIATRY
卷 55, 期 4, 页码 359-366出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2003.11.008
关键词
children; adolescents; development; functional magnetic resonance imaging; mood disorders; orbital-frontal cortex; reward; striatum
资金
- NIMH NIH HHS [P01 MH 041712, K02 MH 001362, K02 MH 064190] Funding Source: Medline
Background: Functional disturbances in reward-related brain systems are thought to play a role in the development of mood, impulse, and substance-abuse disorders. Studies in nonhuman primates have identified brain regions, including the dorsal/ventral striatum and orbital-frontal cortex, in which neural activity is modulated by reward. Recent studies in adults have concurred with these findings by observing reward-contingent blood oxygen level-dependent (BOLD) responses in these regions during functional magnetic resonance imaging (fMRI) paradigms; however, no previous studies indicate whether comparable modulations of neural activity exist in the brain reward systems of children and adolescents. Methods: We used event-related fMRI and a behavioral paradigm modeled on previous work in adults to study brain responses to monetary gains and losses in psychiatrically healthy children and adolescents aspan of a program examining the neural substrates of anxiety and depression in youth. Results. Regions and time-courses of reward-related activity were similar to those observed in adults with condition-dependent BOLD changes in the ventral striatum and lateral and medial orbital-frontal cortex; specifically, these regions showed larger responses to positive than to negative feedback. Conclusions: These results provide further evidence for the value of event-related fMRI in examining reward systems of the brain, demonstrate the feasibility of this approach in children and adolescents, and establish a baseline from which to Understand the pathophysiology of reward-related psychiatric disorders in youth.
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