期刊
BIOLOGICAL PSYCHIATRY
卷 55, 期 4, 页码 346-352出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2003.10.013
关键词
adenine-uracil-rich elements; bipolar disorder; freezer interval; iron-responsive element; major depressive disorder; postmortem interval
资金
- NIMH NIH HHS [P50 MH060398-10, P01 MH042251, P50 MH060398, P50 MH 60398, MH 42251, MH 54844, R01 MH054844-05, P01 MH042251-20] Funding Source: Medline
There are major concerns that specific agonal conditions, including coma and hypoxia, might affect ribonucleic acid (RNA) integrity in postmortem brain studies. We report that agonal factors significantly affect RNA integrity and have a major impact on gene expression profiles in microarrays. in contrast to agonal factors, gender, age, and postmortem factors have less effect on gene expression profiles. The Average Correlation Index is proposed as a method for evaluating RNA integrity on the basis of similarity of microarray profiles. Reducing the variance due to agonal factors is critical in investigating small but validated gene expression differences in messenger RNA levels between psychiatric patients and control subjects.
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