期刊
JOURNAL OF IMMUNOLOGY
卷 172, 期 4, 页码 2296-2306出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.172.4.2296
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资金
- Wellcome Trust [WT061000] Funding Source: Medline
The Hedgehog family of secreted intercellular signaling molecules are regulators of patterning and organogenesis during animal development. In this study we provide genetic evidence that Sonic Hedgehog (Shh) has a role in the control of murine T cell development. Analysis of Shh(-/-) mouse embryos revealed that Shh regulates fetal thymus cellularity and thymocyte differentiation. Shh is necessary for expansion of CD4(-)CD8(-) double-negative (DN) thymocytes and for efficient transition from the earliest CD44(+)CD25(-) DN population to the subsequent CD44(+)CD25(+) DN population and from DN to CD4(+)CD8(+) double-positive cells.
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