期刊
TETRAHEDRON LETTERS
卷 45, 期 8, 页码 1617-1619出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2003.12.124
关键词
ionic liquids; peptide synthesis; aminoacids
We demonstrate that chemical peptide coupling using modern coupling agents is efficient in rt ionic liquids. This new approach presents some advantages, especially in the case of hindered amino acids, which are not easy to couple under standard conditions, since high purities for the crude peptides were observed with respect to coupling in classical solvents. (C) 2004 Elsevier Ltd. All rights reserved.
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