期刊
TETRAHEDRON LETTERS
卷 45, 期 8, 页码 1611-1615出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2003.12.131
关键词
fluorine; peptidomimetics; matrix metalloproteinases
The total synthesis of trifluoromethyl (Tfm) analogs of known nanomolar matrix metalloprotein ases (MMPs) inhibitors has been performed. The synthetic protocol is based on a moderately stereoselective aldol reaction of trifluoropyruvate with an N-acyl-oxazolidin-2-thione for the construction of the core alpha-Tfm-malic unit. Both the diastereomeric forms of the target alpha-Tfm-malic hydroxamates showed micromolar inhibitory potency toward MMP-2 and 9, with a substantial drop with respect to the parent unfluorinated compounds. (C) 2004 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据