期刊
CURRENT BIOLOGY
卷 14, 期 4, 页码 314-321出版社
CELL PRESS
DOI: 10.1016/j.cub.2004.01.052
关键词
-
资金
- NINDS NIH HHS [T32 NS007-067-24, F32 NS046847-03, F32 NS046847, F32 NS046847-02, F32 NS046847-01, 1 F32 NS46847-01, 1R01NS40929-0] Funding Source: Medline
Much attention has focused on dendritic translational regulation of neuronal signaling and plasticity [1, 2]. For example, long-term memory in adult Drosophila requires Pumilio (Pum) [3], an RNA binding protein that interacts with the RNA binding protein Nanos (Nos) to form a localized translation repression complex essential for anterior-posterior body patterning in early embryogenesis [4]. Whether dendrite morphogenesis requires similar translational regulation is unknown. Here we report that nos and pum control the elaboration of high-order dendritic branches of class III and IV, but not class I and II, dendritic arborization (da) neurons. Analogous to their function in body patterning, nos and pum require each other to control dendrite morphogenesis, a process likely to involve translational regulation of nos itself. The control of dendrite morphogenesis by Nos/Pum, however, does not require hunchback, which is essential for body patterning. Interestingly, Nos protein is localized to RNA granules in the dendrites of da neurons, raising the possibility that the Nos/Pum translation repression complex operates in dendrites. This work serves as an entry point for future studies of dendritic translational control of dendrite morphogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据