期刊
ORGANIC LETTERS
卷 6, 期 4, 页码 637-640出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol036480r
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资金
- NIGMS NIH HHS [R01-GM67187] Funding Source: Medline
Trifluoroacetyl derivatives of hydrazines undergo clean and efficient reductive cleavage of the N-N bond with SmI2 in the presence of MeOH. After N-trifluoroacetylation, acyl-, aryl-, and alkyl-substituted hydrazines are reductively cleaved by this method to afford trifluoroacetamides in yields ranging from 70 to 96%. These conditions accommodate alkene functionality, avoid racemization, and furnish chiral amines bearing a readily removable TFA protecting group.
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